Discovery of new G-quadruplex binding chemotypes

Stephan A. Ohnmacht; Ehsan Varavipour; Rupesh Nanjunda; Ingrida Pazitna; Gloria Di Vita; Mekala Gunaratnam; Arvind Kumar; Mohamed A. Ismail; David W. Boykin; W. David Wilson; Stephen Neidle

doi:10.1039/C3CC48616H

Discovery of new G-quadruplex binding chemotypes†

Stephan A. Ohnmacht,^a Ehsan Varavipour,^a Rupesh Nanjunda,^b Ingrida Pazitna,^a Gloria Di Vita,^a Mekala Gunaratnam,^a Arvind Kumar,^b Mohamed A. Ismail,^b David W. Boykin,^b W. David Wilson^b and Stephen Neidle*^a

Author affiliations

* Corresponding authors

^a School of Pharmacy, University College London, London WC1N 1AX, UK
E-mail: s.neidle@ucl.ac.uk
Fax: +44 (0)207 753 5970
Tel: +44 (0)207 753 5969

^b Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30303-3083, USA

Abstract

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

Chemical Communications

Discovery of new G-quadruplex binding chemotypes†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Discovery of new G-quadruplex binding chemotypes

Social activity

Search articles by author

Spotlight

Advertisements