The total synthesis of the antifungal antibiotic, polyoxin J 1 starting from myo-inositol is described; the two key components, 2 and 3, were prepared from a pair of optically resolved myo-inositol derivatives 4L and 4D, respectively, using a highly regioselective Baeyer–Villiger reaction, and finally coupled to complete the total synthesis.
N. Chida, K. Koizumi, Y. Kitada, C. Yokoyama and S. Ogawa, J. Chem. Soc., Chem. Commun., 1994, 111 DOI: 10.1039/C39940000111
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