Issue 35, 2012
From the journal:

Dalton Transactions

Multifunctional magnetic calcium phosphatenanoparticles for targeted platin delivery†

Smruti R. Rout,a   Birendra Behera,b   Tapas K. Maitib  and  Sasmita Mohapatra*a  

* Corresponding authors

a Department of Chemistry, National Institute of Technology, Rourkela-769008, India
E-mail: sasmitam@nitrkl.ac.in
Fax: +91-661-2462651
Tel: +91-661-2462661

b Department of Biotechnology, Indian Institute of Technology, Kharagpur-721302, India

Abstract

Magnetic mesoporous amorphous calcium phosphate nanoparticles with a size of 62 nm and abundant –COOH groups on the surface have been prepared by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. By virtue of the carboxylate groups on the surface, the platinum pharmacophore cis-diaquadiamine platinum(II), folic acid and rhodamine isothiocyanate were conjugated on these magnetic calcium phosphate nanoparticles. The cytotoxicity and internalization efficiency of these nanocarriers have been evaluated on folate receptor overexpressed HeLa cells. These drug loaded nanoagents exhibit elevated cytotoxicity and induce apoptosis in HeLa cells.

Graphical abstract: Multifunctional magnetic calcium phosphate nanoparticles for targeted platin delivery

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Article information

DOI
https://doi.org/10.1039/C2DT30984J
Article type
Paper
Submitted
05 May 2012
Accepted
17 Jul 2012
First published
17 Jul 2012

Dalton Trans., 2012,41, 10777-10783

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Multifunctional magnetic calcium phosphate nanoparticles for targeted platin delivery

S. R. Rout, B. Behera, T. K. Maiti and S. Mohapatra, Dalton Trans., 2012, 41, 10777 DOI: 10.1039/C2DT30984J

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