Issue 14, 2013
From the journal:

Chemical Communications

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation†

Qingzhi Zhang,*a   Agnieszka Kulczynska,a   David J. Webb,b   Ian L. Megson*c  and  Nigel P. Botting‡*a  

* Corresponding authors

a University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UK
E-mail: qz@st-andrews.ac.uk
Fax: +44 (0)1334 463808
Tel: +44 (0)1334 467274

b Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, UK

c Free Radical Research Facility, Department of Diabetes and Cardiovascular Science, The University of The Highlands & Islands, Centre for Health Science, Old Perth Road, Inverness, UK
E-mail: ian.megson@uhi.ac.uk
Fax: +44 (0)1463 711245
Tel: +44 (0)1463 279562

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Graphical abstract: A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

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Article information

DOI
https://doi.org/10.1039/C2CC38382A
Article type
Communication
Submitted
21 Nov 2012
Accepted
20 Dec 2012
First published
21 Dec 2012
This article is Open Access

Chem. Commun., 2013,49, 1389-1391

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A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Q. Zhang, A. Kulczynska, D. J. Webb, I. L. Megson and N. P. Botting, Chem. Commun., 2013, 49, 1389 DOI: 10.1039/C2CC38382A

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