Issue 76, 2012
From the journal:

Chemical Communications

Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates†

Elena Pazos,a   Marko Goličnik,b   José L. Mascareñas*a  and  M. Eugenio Vázquez*a  

* Corresponding authors

a Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, Departamento de Química Orgánica and Unidad Asociada al CSIC. Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: joseluis.mascarenas@usc.es, eugenio.vazquez@usc.es
Fax: +34 981 505 012
Tel: +34 881 815 738

b Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
E-mail: marko.golicnik@mf.uni-lj.si
Fax: +386 15437641
Tel: +386 1 5437669

Abstract

The luminescence of a designed peptide equipped with a coordinatively-unsaturated lanthanide complex is modulated by the phosphorylation state of a serine residue in the sequence. While the phosphorylated state is weakly emissive, even in the presence of an external antenna, removal of the phosphate allows coordination of the sensitizer to the metal, yielding a highly emissive supramolecular complex.

Graphical abstract: Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates

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Article information

DOI
https://doi.org/10.1039/C2CC34958B
Article type
Communication
Submitted
11 Jul 2012
Accepted
01 Aug 2012
First published
16 Aug 2012

Chem. Commun., 2012,48, 9534-9536

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Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates

E. Pazos, M. Goličnik, J. L. Mascareñas and M. Eugenio Vázquez, Chem. Commun., 2012, 48, 9534 DOI: 10.1039/C2CC34958B

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