Mesoporous phosphonate–TiO2 nanoparticles for simultaneous bioresponsive sensing and controlled drug release

Hui Li; Tian-Yi Ma; De-Ming Kong; Zhong-Yong Yuan

doi:10.1039/C2AN36631B

Mesoporous phosphonate–TiO₂nanoparticles for simultaneous bioresponsive sensing and controlled drug release

Hui Li,†^a Tian-Yi Ma,†^b De-Ming Kong*^a and Zhong-Yong Yuan^b

* Corresponding authors

^a State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, P R China
E-mail: kongdem@nankai.edu.cn
Fax: +86-22-23502458
Tel: +86-22-23500938

^b Institute of New Catalytic Materials Science, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, P R China

Abstract

The bioresponsive detection of DNA or proteins and the controlled release of drug molecules are two important research areas for both experimental studies and practical applications. However, the real incorporation of these two functions into one system is still untouched. Being different from the widely reported mesoporous silica nanoparticles that were used as the support, herein we report a smart system based on hybrid phosphonate–TiO₂ mesoporous nanostructures capped with fluorescein labeled oligonucleotides, which can realize simultaneous and highly-efficient biomolecule sensing and controlled drug release. The fluorescence of the labeled oligonucleotides is first quenched by the phosphonate–TiO₂ materials, which are related to the fluorescence resonance energy transfer mechanism. The addition of complementary DNA strands or protein target leads to the displacement of the capped DNA due to hybridization or protein–aptamer reactions. The opening of the pores can further cause the release of entrapped drugs as well as the restoration of dye fluorescence. The present method is proven to have high selectivity towards specific ssDNA and proteins.

Article information

https://doi.org/10.1039/C2AN36631B

Article type

Paper

Submitted

07 Nov 2012

Accepted

14 Dec 2012

First published

17 Dec 2012

Download Citation

Analyst, 2013,138, 1084-1090

Permissions

Request permissions

Mesoporous phosphonate–TiO₂ nanoparticles for simultaneous bioresponsive sensing and controlled drug release

H. Li, T. Ma, D. Kong and Z. Yuan, Analyst, 2013, 138, 1084 DOI: 10.1039/C2AN36631B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Analyst