Issue 24, 2011
From the journal:

Organic & Biomolecular Chemistry

An efficient copper-catalyzed synthesis of anilines by employing aqueous ammonia†

Xin Zeng,ab   Wenming Huang,b   Yatao Qiub  and  Sheng Jiang*b  

* Corresponding authors

a College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 210032, China

b Laboratory of Medicinal Chemistry, Guangzhou Institute of Biomedicine and Health, CAS, Guangzhou, Guangdong 510530, P. R. China
E-mail: jiang_sheng@gibh.ac.cn
Fax: +86-20-32290439

Abstract

Under the catalysis of CuI/2-carboxylic acid-quinoline-N-oxide, the cross coupling reactions between aryl iodides or bromides and aqueous ammonia proceed very well to afford N-unprotected aniline derivatives in excellent yields. This inexpensive catalytic system shows great functional group tolerance and excellent reaction selectivity.

Graphical abstract: An efficient copper-catalyzed synthesis of anilines by employing aqueous ammonia

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Article information

DOI
https://doi.org/10.1039/C1OB06208E
Article type
Communication
Submitted
20 Jul 2011
Accepted
20 Sep 2011
First published
20 Sep 2011

Org. Biomol. Chem., 2011,9, 8224-8227

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An efficient copper-catalyzed synthesis of anilines by employing aqueous ammonia

X. Zeng, W. Huang, Y. Qiu and S. Jiang, Org. Biomol. Chem., 2011, 9, 8224 DOI: 10.1039/C1OB06208E

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