Issue 19, 2011
From the journal:

Organic & Biomolecular Chemistry

Self-assembling dipeptide-based nontoxic vesicles as carriers for drugs and other biologically important molecules†

Jishu Naskar,a   Subhasish Roy,a   Anindita Joardar,b   Sumantra Dasb  and  Arindam Banerjee*a  

* Corresponding authors

a Biological Chemistry Department, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India
E-mail: bcab@iacs.res.in
Fax: +91-33-2473-2805

b Cell Biology & Physiology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India

Abstract

Self-assembling short peptides can offer an opportunity to make useful nano-/microstructures that find potential application in drug delivery. We report here the formation of multivesicular structures from self-assembling water-soluble synthetic amphiphilic dipeptides containing a glutamic acid residue at the C-terminus. These vesicular structures are stable over a wide range of pH (pH 2–12). However, they are sensitive towards calcium ions. This causes the rupturing of these vesicles. Interestingly, these vesicles can not only encapsulate an anticancer drug and a fluorescent dye, but also can release them in the presence of calcium ions. Moreover, these multivesicular structures have the potential to carry biologically important molecules like cyclic adenosine monophosphate (cAMP) within the cells keeping their biological functions intact. A MTT cell-survival assay suggests the almost nontoxic nature of these vesicles. Thus, these peptide vesicles can be used as biocompatible delivery vehicles for carrying drugs and other bioactive molecules.

Graphical abstract: Self-assembling dipeptide-based nontoxic vesicles as carriers for drugs and other biologically important molecules

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Article information

DOI
https://doi.org/10.1039/C1OB05757J
Article type
Paper
Submitted
13 May 2011
Accepted
06 Jul 2011
First published
14 Jul 2011

Org. Biomol. Chem., 2011,9, 6610-6615

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Self-assembling dipeptide-based nontoxic vesicles as carriers for drugs and other biologically important molecules

J. Naskar, S. Roy, A. Joardar, S. Das and A. Banerjee, Org. Biomol. Chem., 2011, 9, 6610 DOI: 10.1039/C1OB05757J

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