Sultone opening with [18F]fluoride: an efficient 18F-labelling strategy for PET imaging

Sébastien Schmitt; Cédric Bouteiller; Louisa Barré; Cécile Perrio

doi:10.1039/C1CC14435A

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Sultone opening with [¹⁸F]fluoride: an efficient ¹⁸F-labelling strategy for PET imaging†

Sébastien Schmitt,^a Cédric Bouteiller,^a Louisa Barré^a and Cécile Perrio*^a

Author affiliations

* Corresponding authors

^a LDM-TEP, CEA/DSV/I2BM/CI-NAPS UMR6232, CNRS, Université de Caen Basse-Normandie, Cyceron, Boulevard Henri Becquerel, 14074 Caen cedex, France
E-mail: perrio@cyceron.fr
Fax: 0033 (0)231470275
Tel: 0033 (0)231470281

Abstract

Sultones were subject to ring opening by nucleophilic attack with [¹⁸F]fluoride to afford easily purified ¹⁸F-labelled hydrophilic sulfonated products in high yields. A two-step sequence including radiofluorination and coupling to lysine was then developed from a bis-sultone precursor as a model approach for the labelling of biopolymers.

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Article information

DOI: https://doi.org/10.1039/C1CC14435A
Article type: Communication
Submitted: 21 Jul 2011
Accepted: 13 Sep 2011
First published: 26 Sep 2011

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Chem. Commun., 2011,47, 11465-11467

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Sultone opening with [¹⁸F]fluoride: an efficient ¹⁸F-labelling strategy for PET imaging

S. Schmitt, C. Bouteiller, L. Barré and C. Perrio, Chem. Commun., 2011, 47, 11465 DOI: 10.1039/C1CC14435A

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