Issue 1, 2011

Methods and options for the heterologous production of complex natural products

Abstract

Covering: 1990 to 2010

Heterologous biosynthesis has emerged as a viable route to access the beneficial properties of natural products. This development primarily owes to the difficulties encountered when using traditional methods of natural product discovery and production. However, the process of heterologous biosynthesis also presents a number of challenges that have produced an array of creative solutions and noteworthy success stories. In this review, a historical perspective will be presented, together with an analysis of the experimental approaches thus far used to address the unique issues associated with heterologous natural product biosynthesis.

Graphical abstract: Methods and options for the heterologous production of complex natural products

Article information

Article type
Review Article
Submitted
01 Sep 2010
First published
09 Nov 2010

Nat. Prod. Rep., 2011,28, 125-151

Methods and options for the heterologous production of complex natural products

H. Zhang, B. A. Boghigian, J. Armando and B. A. Pfeifer, Nat. Prod. Rep., 2011, 28, 125 DOI: 10.1039/C0NP00037J

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