Issue 10, 2011
From the journal:

Analyst

Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer

Tibor Renkecz,a   Giorgio Ceolina  and  Viola Horváth*b  

* Corresponding authors

a Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Szt. Gellért tér 4., Hungary

b Research Group of Technical Analytical Chemistry, Hungarian Academy of Sciences-Budapest University of Technology and Economics, Budapest, Szt. Gellért tér 4., Hungary
E-mail: vhorvath@mail.bme.hu
Fax: +36 1 463 3408

Abstract

Molecularly imprinted polymers (MIPs) were synthesized in 24-well glass fiber membrane filter plates to obtain a novel type of solid phase extraction device for the cleanup of propranolol. Sample processing parameters like residence time during sample loading, sample volume, pH, sample solvent, type and amount of washing and elution solvents were investigated and optimized. Important differences from the traditional molecularly imprinted solid phase extraction (MISPE) cartridges have been identified. The MIP modified composite membrane suits well for the sample preparation of low volume biological samples. A protocol has been elaborated for the quantitation of propranolol from urine and plasma samples in the clinically relevant concentration ranges. Preliminary validation results indicate that the composite MIP membrane filter plates offer a viable alternative to existing MISPE cartridges and at the same time have advantages like much easier and faster synthesis method and high-throughput analysis.

Graphical abstract: Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer

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Article information

DOI
https://doi.org/10.1039/C0AN00906G
Article type
Paper
Submitted
12 Nov 2010
Accepted
28 Feb 2011
First published
29 Mar 2011

Analyst, 2011,136, 2175-2182

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Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer

T. Renkecz, G. Ceolin and V. Horváth, Analyst, 2011, 136, 2175 DOI: 10.1039/C0AN00906G

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