Issue 8, 2010
From the journal:

Green Chemistry

Metal-free tandem reaction in water: An efficient and regioselective synthesis of 3-hydroxyisoindolin-1-ones†

Yu Zhou,a   Yun Zhai,a   Jian Li,a   Deju Ye,a   Hualiang Jianga  and  Hong Liu*a  

* Corresponding authors

a The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China
E-mail: hliu@mail.shcnc.ac.cn
Fax: +86 21-50807042
Tel: +86 21-50807042

Abstract

A mild and effective method was developed for the construction of heterocyclic building blocks 3-hydroxyisoindolin-1-ones via a metal-free tandem transformation with excellent regioselectivity. Significantly, the strategy presents an atom-economical and environmentally friendly transformation, in which two new C–N bonds and one C–O bond are formed in water from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Graphical abstract: Metal-free tandem reaction in water: An efficient and regioselective synthesis of 3-hydroxyisoindolin-1-ones

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C004745G
Article type
Paper
Submitted
29 Mar 2010
Accepted
21 Jun 2010
First published
08 Jul 2010

Green Chem., 2010,12, 1397-1404

Permissions

Request permissions

Metal-free tandem reaction in water: An efficient and regioselective synthesis of 3-hydroxyisoindolin-1-ones

Y. Zhou, Y. Zhai, J. Li, D. Ye, H. Jiang and H. Liu, Green Chem., 2010, 12, 1397 DOI: 10.1039/C004745G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements