Effect of peptide-chelate architecture on the metabolic stability of peptide-based MRI contrast agents

Zhaoda Zhang; Andrew F. Kolodziej; Jianfeng Qi; Shrikumar A. Nair; Xifang Wang; April W. Case; Matthew T. Greenfield; Philip B. Graham; Thomas J. McMurry; Peter Caravan

doi:10.1039/B9NJ00787C

Effect of peptide-chelate architecture on the metabolic stability of peptide-based MRI contrast agents

Zhaoda Zhang,^a Andrew F. Kolodziej,^b Jianfeng Qi,^b Shrikumar A. Nair,^b Xifang Wang,^b April W. Case,^b Matthew T. Greenfield,^b Philip B. Graham,^b Thomas J. McMurry^b and Peter Caravan*^a

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^a A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St., Suite 2301, Charlestown, USA
E-mail: caravan@nmr.mgh.harvard.edu

^b Epix Pharmaceuticals, 4 Maguire Road, Lexington, USA

Abstract

A strategy for preparing high relaxivity, metabolically-stable, peptide-based MR contrast agents is described.

New Journal of Chemistry

Effect of peptide-chelate architecture on the metabolic stability of peptide-based MRI contrast agents

Abstract

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Effect of peptide-chelate architecture on the metabolic stability of peptide-based MRI contrast agents

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