Issue 9, 2009
From the journal:

Journal of Materials Chemistry

Mesoporous silicananoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics

Shih-Hsun Cheng,ac   Chia-Hung Lee,b   Chung-Shi Yang,b   Fan-Gang Tseng,c   Chung-Yuan Moud  and  Leu-Wei Lo*a  

* Corresponding authors

a Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan 350, Taiwan, ROC
E-mail: lwlo@nhri.org.tw
Fax: (+886)37-586440

b Center for Nanomedicine Research, National Health Research Institutes, 35 Keyan Road, Zhunan 350, Taiwan, ROC

c Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 300, Taiwan, ROC

d Department of Chemistry National Taiwan University, Taipei 106, Taiwan, ROC

Abstract

Functionalization of mesoporous silica nanoparticles (MSNs) with Pd-porphyrins for cancer cell photodynamic therapy is reported. The composite platform, MSN–PdTPP, expands the role of Pd-porphyrins from their routine use as phosphorescence probes for oxygen sensing/imaging (diagnostics) to that of novel nano-photosensitizers for cancer cell phototherapy (therapeutics). The utility of MSN–PdTPP in the phototherapeutic treatment of MDA-MB-231 breast cancer cells is also evaluated, suggesting it is a promising cancer theranostic platform.

Graphical abstract: Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B816636F
Article type
Paper
Submitted
24 Sep 2008
Accepted
19 Nov 2008
First published
08 Jan 2009

J. Mater. Chem., 2009,19, 1252-1257

Permissions

Request permissions

Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics

S. Cheng, C. Lee, C. Yang, F. Tseng, C. Mou and L. Lo, J. Mater. Chem., 2009, 19, 1252 DOI: 10.1039/B816636F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements