Issue 20, 2009
From the journal:

Journal of Materials Chemistry

Preparation of a biocompatible stent surface by plasma polymerization followed by chemical grafting of drug compounds

Sun-Jung Song,a   Kyoung Seok Kim,a   Kyung Hwan Kim,a   Hui Jie Li,a   Jong-Ho Kim,ab   Myung Ho Jeong,c   Byung Hoon Kim,d   Yeong Moo Kod  and  Dong Lyun Cho*ab  

* Corresponding authors

a Center for Functional Nano Fine Chemicals & School of Applied Chemical Engineering, Chonnam National University, Gwangju, Korea

b The Research Institute for Catalysis, Chonnam National University, Gwangju, Korea
E-mail: dlcho@chonnam.ac.kr

c The Heart Center of Chonnam National University Hospital, Gwangju, Korea

d Department of Dental Materials, College of Dentistry, 2nd stage of Brain Korea 21, Chosun University, Gwangju, Korea

Abstract

The preparation of a biocompatible stent surface was investigated by plasma polymerization of 1,2-diaminocyclohexane (DACH) followed by chemical grafting of α-lipoic acid (ALA). The plasma polymerization resulted in the deposition of a thin polymer film containing amine groups. ALA could be grafted chemically to the thin film through the formation of an amide bond in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide (carbodiimide). The ALA-grafted film showed good mechanical stability and blood compatibility, and a stent coated with the film was shown to be effective at inhibiting neointimal hyperplasia.

Graphical abstract: Preparation of a biocompatible stent surface by plasma polymerization followed by chemical grafting of drug compounds

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B813357C
Article type
Paper
Submitted
04 Aug 2008
Accepted
19 Feb 2009
First published
26 Mar 2009

J. Mater. Chem., 2009,19, 3248-3252

Permissions

Request permissions

Preparation of a biocompatible stent surface by plasma polymerization followed by chemical grafting of drug compounds

S. Song, K. S. Kim, K. H. Kim, H. J. Li, J. Kim, M. H. Jeong, B. H. Kim, Y. M. Ko and D. L. Cho, J. Mater. Chem., 2009, 19, 3248 DOI: 10.1039/B813357C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements