Issue 16, 2008
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed 1,4-addition of terminal alkynes to unsaturated carbonyl compounds promoted by electron-rich ligands

Lei Zhou,†ab   Liang Chen,†c   Rachid Skouta,b   Huan-feng Jiang*a  and  Chao-Jun Li*bc  

* Corresponding authors

a College of Chemistry, South China University of Technology, Guangzhou, PR China

b Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec, Canada

c Department of Chemistry, Tulane University, New Orleans, Louisiana, USA
E-mail: cj.li@mcgill.ca, jianghf@scut.edu.cn
Fax: +1 514 3983797
Tel: +1 514 3988457

Abstract

The efficient palladium-catalyzed conjugate addition of terminal alkynes to α,β-unsaturated carbonyl compounds has been developed using electron-rich ligands, producing the corresponding γ,δ-alkynyl ketone and γ,δ-alkynyl esters in good yields.

Graphical abstract: Palladium-catalyzed 1,4-addition of terminal alkynes to unsaturated carbonyl compounds promoted by electron-rich ligands

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Article information

DOI
https://doi.org/10.1039/B805946M
Article type
Paper
Submitted
08 Apr 2008
Accepted
16 May 2008
First published
24 Jun 2008

Org. Biomol. Chem., 2008,6, 2969-2977

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Palladium-catalyzed 1,4-addition of terminal alkynes to unsaturated carbonyl compounds promoted by electron-rich ligands

L. Zhou, L. Chen, R. Skouta, H. Jiang and C. Li, Org. Biomol. Chem., 2008, 6, 2969 DOI: 10.1039/B805946M

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