Issue 8, 2008
From the journal:

Analyst

Recent advances in DNA sensors

Serge Cosniera  and  Pascal Mailleyb  

a Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS, Université Joseph Fourier BP 53, 38041 Grenoble Cédex 9, France
E-mail: serge.cosnier@ujf-grenoble.fr
Fax: +33 476 514 267
Tel: +33 476 514 998

b SPrAM UMR 5819 (UJF-CEA-CNRS) DRFMC/SPrAM, CEA de Grenoble 17 rue des Martyrs, 38054 Grenoble Cédex 9, France
E-mail: pascal.mailley@cea.fr
Fax: +33 438 785 145
Tel: +33 438 784 438

Abstract

The concept of DNA biosensors is sustained by the need for rapid and highly sensitive analytical tools for genetic detection. Their implementation is based on three key steps: (i) immobilization of single-stranded oligonucleotide probes onto a substrate; (ii) hybridization and (iii) reading. These steps involve complementary knowledge in various disciplinary fields such as surface physics and chemistry, molecular electrochemistry, micro-technologies, optics, electronics and biochemistry. We present here, in a non-exhaustive way, the recent advances in the two steps of immobilization and detection that rely upon increasing integration of the number of reading points or/and of the reading strategy.

Graphical abstract: Recent advances in DNA sensors

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Article information

DOI
https://doi.org/10.1039/B803083A
Article type
Highlight
First published
02 Jul 2008

Analyst, 2008,133, 984-991

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Recent advances in DNA sensors

S. Cosnier and P. Mailley, Analyst, 2008, 133, 984 DOI: 10.1039/B803083A

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