Issue 4, 2008

Use of samarium diiodide in the field of asymmetric synthesis

Abstract

Samarium diiodide may be a useful reagent in a step of an asymmetric synthesis process. It can release a blocking group in mild conditions, as described in several examples. SmI2 has been used as electron donor in many C–C bond formations in presence of a chiral auxiliary. It can also generate samarium enolates which were subjected to asymmetric protonation. The examples selected in this review of SmI2 methodology concern only the cases where the chiral auxiliary is not retained in the final product.

Graphical abstract: Use of samarium diiodide in the field of asymmetric synthesis

Article information

Article type
Perspective
Submitted
27 Nov 2007
Accepted
31 Jan 2008
First published
26 Feb 2008

New J. Chem., 2008,32, 607-637

Use of samarium diiodide in the field of asymmetric synthesis

K. Gopalaiah and H. B. Kagan, New J. Chem., 2008, 32, 607 DOI: 10.1039/B718330P

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