Issue 47, 2007
From the journal:

Dalton Transactions

Development of pinene-derived N,P ligands and their utility in catalytic asymmetric hydrogenation

J. Johan Verendela  and  Pher G. Andersson*a  

* Corresponding authors

a Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, BMC, Uppsala, Sweden
E-mail: pher.andersson@kemi.uu.se
Fax: +46184713818
Tel: +46184713801

Abstract

New diastereomeric N,P-ligands, derived from the natural product (+)-α-pinene, have been synthesized and evaluated in iridium-catalyzed asymmetric hydrogenation. The ligands are tetrahydroquinoline derivatives synthesized directly from commercially available α-pinene utilizing resolution or recrystallization to separate diastereomers. In reduction of a range of different trisubstituted alkenes the catalysts express very different activities ranging from no activity to high activity. One of the catalysts gives good ee values for some substrates.

Graphical abstract: Development of pinene-derived N,P ligands and their utility in catalytic asymmetric hydrogenation

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Article information

DOI
https://doi.org/10.1039/B713257N
Article type
Paper
Submitted
28 Aug 2007
Accepted
09 Oct 2007
First published
26 Oct 2007

Dalton Trans., 2007, 5603-5610

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Development of pinene-derived N,P ligands and their utility in catalytic asymmetric hydrogenation

J. J. Verendel and P. G. Andersson, Dalton Trans., 2007, 5603 DOI: 10.1039/B713257N

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