Issue 16, 2006
From the journal:

Organic & Biomolecular Chemistry

Synthetic functional π-stack architecture in lipid bilayers

Sheshanath Bhosale,a   Adam L. Sisson,a   Naomi Sakaia  and  Stefan Matile*a  

* Corresponding authors

a Department of Organic Chemistry, University of Geneva, Geneva, Switzerland
E-mail: stefan.matile@chiorg.unige.ch
Fax: +41 22 379 5123
Tel: +41 22 379 6523

Abstract

Neglected until recently, π-stack architecture is rapidly emerging as a powerful strategy to create function in lipid bilayer membranes. Recent reports describe supramolecular rosettes acting as hosts of intercalating guests, to assemble in bilayer membranes and, in the case of stacked guanosine and folate quartets, to form ion channels. The introduction of rigid-rod π-stack architecture allowed us to address one of the great challenges in the field, i.e. ligand gating. Inspiring π-stack chemistry from related fields, covering rainbow coloration, conductivity, as well as the critical dependence of charge mobilities on the precision of supramolecular organization is summarized to zoom in on arguably the most promising application of functional π-stack architecture in lipid bilayers, that is the creation of multifunctional photosystems.

Graphical abstract: Synthetic functional π-stack architecture in lipid bilayers

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Article information

DOI
https://doi.org/10.1039/B606487F
Article type
Emerging Area
Submitted
09 May 2006
Accepted
13 Jun 2006
First published
07 Jul 2006

Org. Biomol. Chem., 2006,4, 3031-3039

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Synthetic functional π-stack architecture in lipid bilayers

S. Bhosale, A. L. Sisson, N. Sakai and S. Matile, Org. Biomol. Chem., 2006, 4, 3031 DOI: 10.1039/B606487F

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