Issue 24, 2006
From the journal:

Chemical Communications

Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes†

Satoshi Mizuta,a   Norio Shibata,*a   Shinichi Ogawa,a   Hiroyuki Fujimoto,a   Shuichi Nakamuraa  and  Takeshi Toru*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Japan
E-mail: nozshiba@nitech.ac.jp, toru@nitech.ac.jp
Fax: +81 52-735-5442
Tel: +81 52-735-7543

Abstract

The first Lewis acid-catalyzed trifluoromethylation reactions of aldehydes with Me3SiCF3 under TiF4/DMF, Ti(OiPr)4/DMF and Cu(OAc)2/dppp/toluene conditions are described. We have successfully applied this methodology to the difluoromethylation of aldehydes using Me3SiCF2SePh, Me3SiCF2P(O)OEt2 and Me3SiCF2SPh.

Graphical abstract: Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes

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Article information

DOI
https://doi.org/10.1039/B603041F
Article type
Communication
Submitted
28 Feb 2006
Accepted
25 Apr 2006
First published
10 May 2006

Chem. Commun., 2006, 2575-2577

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Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes

S. Mizuta, N. Shibata, S. Ogawa, H. Fujimoto, S. Nakamura and T. Toru, Chem. Commun., 2006, 2575 DOI: 10.1039/B603041F

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