Issue 22, 2002

Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica

Abstract

Structurally unique isocoumarin glucosides, named halorosellins A (1) and B (2), were isolated from the EtOAc extract of a broth of the marine fungus Halorosellinia oceanica. Other new minor metabolites including 4,8-dihydroxy-6-methoxy-4,5-dimethyl-3-methyleneisochroman-1-one (3), 3-acetyl-7-hydroxy-5-methoxy-3,4-dimethyl-3H-isobenzofuran-1-one (4) and an ophiobolane sesterterpene, 17-dehydroxyhalorosellinic acid (5), were also isolated. Structures of these compounds were elucidated by analyses of spectroscopic data. Compound 4 exhibited mild antimycobacterial activity (MIC value of 200 µg mL−1).

Graphical abstract: Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica

Article information

Article type
Paper
Submitted
12 Aug 2002
Accepted
04 Sep 2002
First published
15 Oct 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2473-2476

Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica

M. Chinworrungsee, P. Kittakoop, M. Isaka, R. Chanphen, M. Tanticharoen and Y. Thebtaranonth, J. Chem. Soc., Perkin Trans. 1, 2002, 2473 DOI: 10.1039/B207887M

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