Issue 8, 2002

A convenient preparation of several N-linked glycoamino acid building blocks for efficient solid-phase synthesis of glycopeptides

Abstract

A convenient, high yielding route for the preparation of several Boc- and Fmoc-protected N-linked glycopeptide monomers is presented. These building blocks can be used for the solid-phase synthesis of glycopeptides or glycopeptidomimetics, which is exemplified by the preparation of an N-linked dodecaglycopeptide Ac–(GlyProAsn[Gal])4–NH2, a potential collagen mimic.

Graphical abstract: A convenient preparation of several N-linked glycoamino acid building blocks for efficient solid-phase synthesis of glycopeptides

Article information

Article type
Paper
Submitted
05 Feb 2002
Accepted
04 Mar 2002
First published
22 Mar 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1042-1049

A convenient preparation of several N-linked glycoamino acid building blocks for efficient solid-phase synthesis of glycopeptides

J. van Ameijde, H. B. Albada and R. M. J. Liskamp, J. Chem. Soc., Perkin Trans. 1, 2002, 1042 DOI: 10.1039/B201296K

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