Issue 1, 2001
From the journal:

Green Chemistry

Integrated chemical process for green chemistry. One-pot synthesis of 3-substituted 5-(β-sulfonylvinyl)indoles by in situ generation of toxic vinyl sulfone

Akihiro Orita,a   Masataka Katakami,a   Yutaka Yasui,a   Akio Kuriharab  and  Junzo Otera*a  

* Corresponding authors

a Department of Applied Chemistry, Okayama University of Science, Ridai-cho, Okayama, Japan.
E-mail: otera@high.ous.ac.jp

b Organic Synthesis Research Laboratory, Sumitomo Chemical Co., Ltd., 10-1 2-Chome Tsukahara Takatsuki-City, Osaka, JapanFirst published as an Advance Article on the web

Abstract

Integrated chemical processes where multi-step reactions are consolidated in one pot are effective for realizing a green chemical process. In situ generation followed by consumption of toxic intermediates which are formed in the process enables their complete isolation from the environment. This is so for a vinyl sulfone intermediate in the synthesis of 3-substituted 5-(β-sulfonylvinyl)indoles. The validity of this idea is further confirmed by successful one-pot operations on an automated synthesizer.

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Article information

DOI
https://doi.org/10.1039/B005645F
Article type
Paper
Submitted
12 Jul 2000
First published
08 Jan 2001

Green Chem., 2001,3, 13-16

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Integrated chemical process for green chemistry. One-pot synthesis of 3-substituted 5-(β-sulfonylvinyl)indoles by in situ generation of toxic vinyl sulfone

A. Orita, M. Katakami, Y. Yasui, A. Kurihara and J. Otera, Green Chem., 2001, 3, 13 DOI: 10.1039/B005645F

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