Issue 12, 1986
From the journal:

Analyst

Applications of xanthene derivatives in analytical chemistry. Part LVII. Spectrophotometric determination of minocycline using gallium and Eosin

Itsuo Mori,   Yoshikadzu Fujita,   Hiroshi Kawabe,   Kinuko Fujita,   Takeshi Tanaka  and  Atsuko Kishimoto  

Abstract

A spectrophotometric method for the determination of micro-amounts of minocycline (MINO) as a tetracycline derivative in weakly acidic media is proposed. It is based on the formation of a ternary complex between Eosin (sodium 2,4,5,7-tetrabromofluorescein), gallium and MINO in the presence of poly(vinyl alcohol). Under optimum conditions, minocycline hydrochloride (MINO.HCl) was determined in the range 0–40 µg in 10 ml of solution at 545 nm. The apparent molar absorptivity of MINO.HCl was 1.1 × 105 l mol–1 cm–1 with a Sandell sensitivity of 0.0047 µg cm–2 MINO.HCl. The method was applied to the determination of MINO.HCl in pharmaceutical preparations.

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Article information

DOI
https://doi.org/10.1039/AN9861101409
Article type
Paper

Analyst, 1986,111, 1409-1412

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Applications of xanthene derivatives in analytical chemistry. Part LVII. Spectrophotometric determination of minocycline using gallium and Eosin

I. Mori, Y. Fujita, H. Kawabe, K. Fujita, T. Tanaka and A. Kishimoto, Analyst, 1986, 111, 1409 DOI: 10.1039/AN9861101409

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