SCHEDULED MAINTENANCE
Mild hydrolysis of the broad-spectrum anaerobic antibacterial and antiparasitic agent nitazoxanide 1 affords tizoxanide 2, which is a major metabolite of 1 retaining most of its activity; further metabolism of 2 leads to the O-aryl glucuronide 3, efficiently synthesised in four steps from benzyl salicylate and showing slight antibacterial activity.
J. Rossignol and A. V. Stachulski, J. Chem. Res. (S), 1999, 44 DOI: 10.1039/A806676K
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