Issue 21, 1998

2,3-Methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution

Abstract

Peptidomimetics 1 and 2 of RN24 (an RNase A C-peptide analog) in which the Arg+-10 residue is replaced by 2R,3S-cyclo-Arg′ and by 2S,3S-cyclo-Arg′, respectively, show less temperature dependence in CD studies than the parent peptide.

Article information

Article type
Paper

Chem. Commun., 1998, 2375-2376

2,3-Methanoamino acid analogs of Arg stabilize secondary structures of a 13 amino acid peptide in aqueous solution

D. Lim, D. Moye-Sherman, I. Ham, S. Jin, K. Burgess and J. Martin Scholtz, Chem. Commun., 1998, 2375 DOI: 10.1039/A805367G

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