Issue 10, 1997

Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide

Abstract

A convenient synthesis of the important metabolite 7-hydroxycoumarin glucuronide 3 is presented, including a first report of the β-imidate 11β, together with new preparations of the iodosugar 6 and α-imidate 11α: stability data on 11α and 11β are also given, and the importance of carefully controlled hydrolysis in the last step of the preparation of 3 is emphasised.

Article information

Article type
Paper

J. Chem. Res. (S), 1997, 370-371

Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide

R. T. Brown, F. Scheinmann and A. V. Stachulski, J. Chem. Res. (S), 1997, 370 DOI: 10.1039/A703397B

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