Issue 15, 1997

Chemoselective backbone cyclization of unprotected peptides

Abstract

A fully unprotected 15 residue peptide containing an N-terminal Cys residue and a C-terminal thioester moiety is cleanly converted to the corresponding head-to-tail cyclic peptide in aqueous buffers at around neutral pH.

Article information

Article type
Paper

Chem. Commun., 1997, 1369-1370

Chemoselective backbone cyclization of unprotected peptides

J. A. Camarero and T. W. Muir, Chem. Commun., 1997, 1369 DOI: 10.1039/A702083J

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