Issue 37, 2022

Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator

Abstract

Herein, we introduce the first diphenylalanine dipeptide hydrogelator capped with the cinnamoyl functional group (Cin-L-F-L-F). We evaluate the effects of the cinnamoyl moiety on molecular self-assembly events and resultant physical properties of the hydrogel formed. In addition, we report our preliminary results of this dipeptide's cytotoxicity against glioblastoma (GBM) cancer cells.

Graphical abstract: Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator

Supplementary files

Article information

Article type
Paper
Submitted
25 Jul 2022
Accepted
01 Sep 2022
First published
12 Sep 2022
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2022,20, 7458-7466

Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator

E. D. Sitsanidis, P. M. Kasapidou, J. R. Hiscock, V. Gubala, H. Castel, P. I. A. Popoola, A. J. Hall and A. A. Edwards, Org. Biomol. Chem., 2022, 20, 7458 DOI: 10.1039/D2OB01339H

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