Synthesis of silver nanoparticles coupled with aromatic diselenides: greener approach, potential against glioma cells and DNA interaction

Sumbal Saba; Natalia B. Preve; Isis J. A. Granja; Gabriela J. Pedroso; Climei R. Cabreira; Juliana P. Dreyer; Luiz F. B. Ribeiro; Ana P. Horn; Marcelo A. G. Marinho; Ismael C. Bellettini; Claus T. Pich; Lucas T. F. Kokuszi; Eduardo Borges; Vânia R. de Lima; Jamal Rafique; Tiago E. A. Frizon

doi:10.1039/D2NJ04810H

Synthesis of silver nanoparticles coupled with aromatic diselenides: greener approach, potential against glioma cells and DNA interaction†

Sumbal Saba,

*^a Natalia B. Preve,^b Isis J. A. Granja,^a Gabriela J. Pedroso,^b Climei R. Cabreira,^c Juliana P. Dreyer,^d Luiz F. B. Ribeiro,^b Ana P. Horn,^e Marcelo A. G. Marinho,^e Ismael C. Bellettini,

^f Claus T. Pich,

^b Lucas T. F. Kokuszi,

^g Eduardo Borges,^g Vânia R. de Lima,^g Jamal Rafique

*^ac and Tiago E. A. Frizon*^b

Author affiliations

* Corresponding authors

^a Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, Brazil
E-mail: sumbalsaba@ufg.br

^b Department of Energy and Sustainability, Federal University of Santa Catarina, Araranguá, SC, Brazil
E-mail: tiago.frizon@ufsc.br

^c Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
E-mail: jamal.rafique@ufms.br, jamal.chm@gmail.com
Web: https://sintmol.ufms.br/

^d Department of Chemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil

^e Institute of Biological Sciences, Post-Graduate Program in Physiological Sciences, Federal University of Rio Grande, Rio Grande, RS, Brazil

^f Department of Exact Sciences and Education, Federal University of Santa Catarina, Blumenau, SC, Brazil

^g Escola de Química e Alimentos, Programa de Pós-Graduação em Química Tecnológica e Ambiental, Universidade Federal do Rio Grande, RS, Brazil

Abstract

This work reports the direct synthesis of organochalcogen-modified silver nanoparticles (A1-7), their cytotoxic potentials against glioma cells (C6) and their interaction with DNA. The influence of the presence of electron-withdrawing and donating groups on the structures of the diselenide were evaluated. MTT data suggest that A3 and A6 reduced C6 cell viability via an addictive effect of the organochalcogen and silver and that the A7 activity had been only attributed to the silver component of the nanoparticle. A3, A6 and A7 showed interaction with DNA by intercalation and, at higher concentrations, a groove binding prevalence was observed.

This article is part of the themed collection: 50th anniversary of ICCST: celebrating ICCST at its 15th Edition

New Journal of Chemistry

Synthesis of silver nanoparticles coupled with aromatic diselenides: greener approach, potential against glioma cells and DNA interaction†

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Synthesis of silver nanoparticles coupled with aromatic diselenides: greener approach, potential against glioma cells and DNA interaction

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