Development of highly efficient Friedel–Crafts alkylations with alcohols using heterogeneous catalysts under continuous-flow conditions

Koichiro Masuda; Yukiko Okamoto; Shun-ya Onozawa; Nagatoshi Koumura; Shū Kobayashi

doi:10.1039/D1RA04005G

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Development of highly efficient Friedel–Crafts alkylations with alcohols using heterogeneous catalysts under continuous-flow conditions†

Koichiro Masuda,

*^a Yukiko Okamoto,^a Shun-ya Onozawa,^a Nagatoshi Koumura^a and Shū Kobayashi

*^ab

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* Corresponding authors

^a Interdisciplinary Research Center for Catalytic Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan
E-mail: koichiro-masuda@aist.go.jp, shu_kobayashi@chem.s.u-tokyo.ac.jp

^b Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract

The development of Friedel–Crafts alkylations with alcohols under continuous-flow conditions using heterogeneous catalysts is reported. The reactivities and durabilities of the examined catalysts were systematically investigated, which showed that montmorillonite clay is the best catalyst for these reactions. A high turnover frequency of 9.0 × 10² h⁻¹ was recorded under continuous-flow conditions, and the continuous operation was successfully maintained over one week.

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DOI: https://doi.org/10.1039/D1RA04005G
Article type: Paper
Submitted: 23 May 2021
Accepted: 05 Jul 2021
First published: 13 Jul 2021
This article is Open Access

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RSC Adv., 2021,11, 24424-24428

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Development of highly efficient Friedel–Crafts alkylations with alcohols using heterogeneous catalysts under continuous-flow conditions

K. Masuda, Y. Okamoto, S. Onozawa, N. Koumura and S. Kobayashi, RSC Adv., 2021, 11, 24424 DOI: 10.1039/D1RA04005G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Development of highly efficient Friedel–Crafts alkylations with alcohols using heterogeneous catalysts under continuous-flow conditions†

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Development of highly efficient Friedel–Crafts alkylations with alcohols using heterogeneous catalysts under continuous-flow conditions

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