To tackle the challenge of CO₂ photoreduction, semiconducting layered transition metal dichalcogenides like MoS₂ have attracted much attention due to their tunable 2D nano-structures. By using advanced periodic density functional theory calculations (HSE06 functional), we provide a systematic quantification of the optoelectronic properties of various interfacial heterostructures composed of 2H-MoS₂ and anatase TiO₂. We systematically determine the band gaps, and conduction band (CB) and valence band (VB) positions to figure out the nature of the heterojunction. Two main surface orientations of anatase TiO₂ particles, (101) and (001), are considered with 2D-MoS₂ nanosheets or nanoribbons forming either a 2D physical (van der Waals) or through a 1D chemical interface. The possibility to chemically modify the MoS₂/TiO₂ interface, either by sulfidation or hydration, and its effect on the electronic structure are deeply investigated. These modifications in the heterostructure lead to important changes in the electronic properties and charge transfer between the two materials which impact both photon absorption properties and charge carrier dynamics suspected to influence in turn the photocatalytic activity. While a type I hetrojunction is found for the 1D chemical interface, a type II heterojunction with appropriate CB/VB positions for CO₂ reduction and H₂O oxidation is identified for the 2D physical interface which could lead to the targeted Z-scheme mechanism with strong potential interest in photocatalysis applications.