The synthesis of N,N′-disulfanediyl-bis(N′-((E)-benzylidene)acetohydrazide) from (E)-N′-benzylideneacetohydrazide and S8

Hong-Yan Liu; Yu Chen; Li-Qiang Hao; Guo-Dong Wang; Hong-Shuang Li; Cheng-Cai Xia

doi:10.1039/D0RA08441G

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The synthesis of N,N′-disulfanediyl-bis(N′-((E)-benzylidene)acetohydrazide) from (E)-N′-benzylideneacetohydrazide and S₈†

Hong-Yan Liu,^a Yu Chen,^b Li-Qiang Hao,^a Guo-Dong Wang,^a Hong-Shuang Li

^a and Cheng-Cai Xia

*^a

Author affiliations

* Corresponding authors

^a School of Pharmacy College, Institute of Pharmacology, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China
E-mail: xiachc@163.com

^b School of Shandong Polytechnic College, Jining, China

Abstract

Herein we report an oxidative coupling reaction for N–S/S–S bond formation from (E)-N′-benzylideneacetohydrazide and S₈ to furnish substituted N,N′-disulfanediyl-bis(N′-((E)-benzylidene) acetohydrazide). It provides a direct approach for the synthesis of disulfides with good yields.

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DOI: https://doi.org/10.1039/D0RA08441G
Article type: Paper
Submitted: 03 Oct 2020
Accepted: 31 Oct 2020
First published: 11 Nov 2020
This article is Open Access

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RSC Adv., 2020,10, 41041-41046

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The synthesis of N,N′-disulfanediyl-bis(N′-((E)-benzylidene)acetohydrazide) from (E)-N′-benzylideneacetohydrazide and S₈

H. Liu, Y. Chen, L. Hao, G. Wang, H. Li and C. Xia, RSC Adv., 2020, 10, 41041 DOI: 10.1039/D0RA08441G

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