Issue 38, 2020

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Abstract

We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.

Graphical abstract: Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Supplementary files

Article information

Article type
Communication
Submitted
28 Feb 2020
Accepted
18 Mar 2020
First published
08 Apr 2020

Chem. Commun., 2020,56, 5186-5189

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

M. P. O’Hagan, J. Ramos-Soriano, S. Haldar, S. Sheikh, J. C. Morales, A. J. Mulholland and M. C. Galan, Chem. Commun., 2020, 56, 5186 DOI: 10.1039/D0CC01581D

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