Issue 24, 2019

Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Abstract

Effective solutions are necessary for biomaterial-associated infections caused by bacteria adhesion and subsequent biofilm formation on the surface of biomedical implants/devices. Current antibacterial coatings are usually vulnerable, and their bactericidal efficacy is impaired or even eliminated upon scratching or abrasion. Thus, self-healable coatings capable of repairing defects themselves are highly desirable. In this work, N-decyl polyethyleneimine (DPEI), a cationic amphiphilic polymer able to self-assemble into micelles in water to concentrate the density of cationic charge, exhibited enhanced antibacterial activity towards the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative Pseudomonas aeruginosa (P. aeruginosa). A layer-by-layer (LbL) assembled coating was prepared using DPEI micelles and polyacrylic acid (PAA), which could reduce more than 90% bacterial adhesion and prevent biofilm formation. In addition, the DPEI/PAA LbL-assembled coating remained stable even with rinsing in physiological saline for up to three weeks owing to the strong interaction induced by its high charge. More importantly, this antibacterial DPEI/PAA LbL-assembled coating achieved self-healing quickly under wet conditions after being scratched, preventing bacteria from adhering to the damaged areas and forming a biofilm. Importantly, this coating avoids the use of antibiotics, which is less likely to cause drug-resistance. In addition, this coating is also biocompatible with mammalian cells (C2C12 mouse myoblast). All these excellent properties endow this self-healing DPEI/PAA LbL-assembled coating with promising prospects for biomedical application.

Graphical abstract: Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Supplementary files

Article information

Article type
Paper
Submitted
12 Mar 2019
Accepted
14 May 2019
First published
15 May 2019

J. Mater. Chem. B, 2019,7, 3865-3875

Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Q. Wang, L. Wang, L. Gao, L. Yu, W. Feng, N. Liu, M. Xu, X. Li, P. Li and W. Huang, J. Mater. Chem. B, 2019, 7, 3865 DOI: 10.1039/C9TB00498J

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