Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761

Hong-Xin Liu; Hai-Bo Tan; Kai Chen; Li-Yun Zhao; Yu-Chan Chen; Sai-Ni Li; Hao-Hua Li; Wei-Min Zhang

doi:10.1039/C8OB03223H

Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761†

Hong-Xin Liu,‡^a Hai-Bo Tan,‡^b Kai Chen,

^cd Li-Yun Zhao,^b Yu-Chan Chen,^a Sai-Ni Li,^a Hao-Hua Li^a and Wei-Min Zhang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
E-mail: wmzhang@gdim.cn

^b Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

^c College of Materials Science and Engineering, South China University of Forestry and Technology, Changsha 410004, China

^d School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China

Abstract

Four novel benzophenone derivatives, cytosporins A–D (1–4), hemiterpene-conjugated phenolics with an unprecedented benzo[b][1,5]dioxocane skeleton, were isolated from Cytospora rhizophorae A761. The structures of the new compounds were fully characterized on the basis of extensive spectroscopic analysis. The deduced structure represents the first example of natural meroterpenoids which bear a benzo[b][1,5]dioxocane framework embodying hemiterpene and benzophenone moieties. Moreover, compounds 1–4 were evaluated for in vitro antimicrobial activity.

This article is part of the themed collection: Chemical Biology in OBC

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DOI: https://doi.org/10.1039/C8OB03223H
Article type: Communication
Submitted: 31 Dec 2018
Accepted: 06 Feb 2019
First published: 11 Feb 2019

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Org. Biomol. Chem., 2019,17, 2346-2350

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Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761

H. Liu, H. Tan, K. Chen, L. Zhao, Y. Chen, S. Li, H. Li and W. Zhang, Org. Biomol. Chem., 2019, 17, 2346 DOI: 10.1039/C8OB03223H

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Organic & Biomolecular Chemistry

Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761†

Abstract

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Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761

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