Issue 42, 2018
From the journal:

Organic & Biomolecular Chemistry

New Friedel–Crafts strategy for preparing 3-acylindoles†

Lian-Hua Li,a   Zhi-Jie Niua  and  Yong-Min Liang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: liangym@lzu.edu.cn

Abstract

A selective Friedel–Crafts acylation of indoles via an unusual cleavage of the amide C–N bond was achieved by triflic anhydride activation. This method offers rapid efficient access to high-biological-value 3-acylindoles, performs a series of scrupulous mechanistic studies and offers a strong courage that amide synthons can form new C–C bonds under transition-metal-free conditions.

Graphical abstract: New Friedel–Crafts strategy for preparing 3-acylindoles

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Article information

DOI
https://doi.org/10.1039/C8OB02094A
Article type
Communication
Submitted
27 Aug 2018
Accepted
02 Oct 2018
First published
03 Oct 2018

Org. Biomol. Chem., 2018,16, 7792-7796

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New Friedel–Crafts strategy for preparing 3-acylindoles

L. Li, Z. Niu and Y. Liang, Org. Biomol. Chem., 2018, 16, 7792 DOI: 10.1039/C8OB02094A

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