Issue 30, 2018

Cobalt(ii)-catalyzed regioselective C–H halogenation of anilides

Abstract

A cobalt-catalyzed regioselective C–H halogenation methodology is reported herein. The highlight of this work is the highly selective C–H functionalization of anilides, which results in high-yielding, versatile, and practical halogenated products. Thereby, brominations, chlorinations and iodinations of many electron-rich and electron-deficient anilides were achieved in a highly selective fashion. Mechanistic studies with respect to the pathway of the reaction are also described.

Graphical abstract: Cobalt(ii)-catalyzed regioselective C–H halogenation of anilides

Supplementary files

Article information

Article type
Paper
Submitted
20 Jun 2018
Accepted
10 Jul 2018
First published
10 Jul 2018

Org. Biomol. Chem., 2018,16, 5433-5440

Cobalt(II)-catalyzed regioselective C–H halogenation of anilides

Z. Li, K. Sun and C. Cai, Org. Biomol. Chem., 2018, 16, 5433 DOI: 10.1039/C8OB01448E

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