Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

Jun Hu; Wen Lei; Jiang Wang; Hong-Yuan Chen; Jing-Juan Xu

doi:10.1039/C8CC08510B

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Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase†

Jun Hu,‡^a Wen Lei,‡^a Jiang Wang,^a Hong-Yuan Chen^a and Jing-Juan Xu

*^a

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* Corresponding authors

^a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
E-mail: xujj@nju.edu.cn
Fax: +86-25-89687294
Tel: +86-25-89687294

Abstract

Herein, we present a rapid, efficient and regioselective phosphorylation method at the 5′-position of unprotected ribose and ribonucleosides with pyrophosphate in the gas phase, which involves the formation of anionic complexes via electrospray ionization and collisional activation to induce phosphorylation within the complexes.

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Article information

DOI: https://doi.org/10.1039/C8CC08510B
Article type: Communication
Submitted: 24 Oct 2018
Accepted: 15 Nov 2018
First published: 15 Nov 2018

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Chem. Commun., 2019,55, 310-313

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Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

J. Hu, W. Lei, J. Wang, H. Chen and J. Xu, Chem. Commun., 2019, 55, 310 DOI: 10.1039/C8CC08510B

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Chemical Communications

Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase†

Abstract

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Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

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