Issue 60, 2018
From the journal:

Chemical Communications

Redox-responsive cisplatin nanogels for anticancer drug delivery†

Weiqi Zhang ORCID logo a  and  Ching-Hsuan Tung ORCID logo *a  

* Corresponding authors

a Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, Cornell University, 413 East 69th Street, Box 290, New York, NY 10021, USA
E-mail: cht2018@med.cornell.edu

Abstract

Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.

Graphical abstract: Redox-responsive cisplatin nanogels for anticancer drug delivery

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CC01795F
Article type
Communication
Submitted
05 Mar 2018
Accepted
02 Jul 2018
First published
03 Jul 2018

Chem. Commun., 2018,54, 8367-8370

Permissions

Request permissions

Redox-responsive cisplatin nanogels for anticancer drug delivery

W. Zhang and C. Tung, Chem. Commun., 2018, 54, 8367 DOI: 10.1039/C8CC01795F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements