Issue 18, 2018, Issue in Progress

Enhancement of cellular glucose uptake by reactive species: a promising approach for diabetes therapy

Abstract

It is generally known that antidiabetic activity is associated with an increased level of glucose uptake in adipocytes and skeletal muscle cells. However, the role of exogenous reactive oxygen and nitrogen species (RONS) in muscle development and more importantly in glucose uptake is largely unknown. We investigate the effect of RONS generated by cold atmospheric plasma (CAP) in glucose uptake. We show that the glucose uptake is significantly enhanced in differentiated L6 skeletal muscle cells after CAP treatment. We also observe a significant increase of the intracellular Ca++ and ROS level, without causing toxicity. One of the possible reasons for an elevated level of glucose uptake as well as intracellular ROS and Ca++ ions is probably the increased oxidative stress leading to glucose transport.

Graphical abstract: Enhancement of cellular glucose uptake by reactive species: a promising approach for diabetes therapy

Article information

Article type
Paper
Submitted
17 Dec 2017
Accepted
03 Mar 2018
First published
08 Mar 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 9887-9894

Enhancement of cellular glucose uptake by reactive species: a promising approach for diabetes therapy

N. Kumar, P. Shaw, J. Razzokov, M. Yusupov, P. Attri, H. S. Uhm, E. H. Choi and A. Bogaerts, RSC Adv., 2018, 8, 9887 DOI: 10.1039/C7RA13389H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements