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Effect of mTHPC-mediated photodynamic therapy on 5-fluorouracil resistant human colorectal cancer cells

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Abstract

The primary or acquired cancer chemoresistance is a major problem in the treatment of cancer patients. It could be overcome by non-overlapping treatment regimens such as photodynamic therapy (PDT). PDT is based on the oxidation of cellular components which occurs when a light-excited photosensitizer generates reactive oxygen species (ROS). In this study the effect of mTHPC mediated PDT (mTHPC-PDT) on 5-FU resistant colorectal cancer (CRC) cells HCT116 was investigated. The results show that mTHPC-PDT overcomes 5-FU resistance and is effective against chemoresistant colorectal carcinoma cells.

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Authors and Affiliations

  1. Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania

    E. Kukcinaviciute, A. Sasnauskiene, D. Dabkeviciene, V. Kirveliene & V. Jonusiene

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  1. E. Kukcinaviciute
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  2. A. Sasnauskiene
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  3. D. Dabkeviciene
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  4. V. Kirveliene
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  5. V. Jonusiene
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Correspondence to V. Jonusiene.

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Kukcinaviciute, E., Sasnauskiene, A., Dabkeviciene, D. et al. Effect of mTHPC-mediated photodynamic therapy on 5-fluorouracil resistant human colorectal cancer cells. Photochem Photobiol Sci 16, 1063–1070 (2017). https://doi.org/10.1039/c7pp00014f

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  • DOI: https://doi.org/10.1039/c7pp00014f

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