Issue 82, 2017
From the journal:

Chemical Communications

S-Nitrosothiols: chemistry and reactions†

Caihong Zhang,ab   Tyler D. Biggs,b   Nelmi O. Devarie-Baez,c   Shaomin Shuang, ORCID logo a   Chuan Dong ORCID logo *a  and  Ming Xian ORCID logo *ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Institute of Environmental Science Shanxi University, Taiyuan, Shanxi, China
E-mail: dc@sxu.edu.cn

b Department of Chemistry, Washington State University, Pullman, WA 99164, USA
E-mail: mxian@wsu.edu

c Department of Chemistry, Washington State University Tri-Cities, Richland, WA 99354, USA

Abstract

The formation of S-nitrosothiols (SNO) in protein cysteine residues is an important post-translational modification elicited by nitric oxide (NO). This process is involved in virtually every class of cell signaling and has attracted considerable attention in redox biology. On the other hand, their unique structural characters make SNO potentially useful synthons. In this review, we summarized the fundamental chemical/physical properties of SNO. We also highlighted the reported chemical reactions of SNO, including the reactions with phosphine reagents, sulfinic acids, various nucleophiles, SNO-mediated radical additions, and the reactions of acyl SNO species.

Graphical abstract: S-Nitrosothiols: chemistry and reactions

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Article information

DOI
https://doi.org/10.1039/C7CC06574D
Article type
Feature Article
Submitted
21 Aug 2017
Accepted
18 Sep 2017
First published
18 Sep 2017

Chem. Commun., 2017,53, 11266-11277

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S-Nitrosothiols: chemistry and reactions

C. Zhang, T. D. Biggs, N. O. Devarie-Baez, S. Shuang, C. Dong and M. Xian, Chem. Commun., 2017, 53, 11266 DOI: 10.1039/C7CC06574D

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