Issue 55, 2017
From the journal:

Chemical Communications

pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing†

Koji Miki, ORCID logo *a   Kentaro Kojima,a   Kazuaki Oride,a   Hiroshi Harada,b   Akiyo Morinibub  and  Kouichi Ohe ORCID logo *a  

* Corresponding authors

a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: kojimiki@scl.kyoto-u.ac.jp, ohe@scl.kyoto-u.ac.jp

b Laboratory of Cancer Cell Biology, Radiation Biology Center, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan

Abstract

Indocyanine green (ICG) derivatives having nucleophilic substituents were synthesized as pH-responsive near-infrared dyes. pH-responsive dyes 1-C with closed-ring structures smoothly internalized and converted to emissive open-ring structures 1-O in response to relatively low pHs in acidic intracellular compartments of HeLa cells.

Graphical abstract: pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing

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Article information

DOI
https://doi.org/10.1039/C7CC03035E
Article type
Communication
Submitted
20 Apr 2017
Accepted
19 Jun 2017
First published
19 Jun 2017

Chem. Commun., 2017,53, 7792-7795

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pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing

K. Miki, K. Kojima, K. Oride, H. Harada, A. Morinibu and K. Ohe, Chem. Commun., 2017, 53, 7792 DOI: 10.1039/C7CC03035E

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