Issue 24, 2017
From the journal:

Analytical Methods

Screen-printed graphene-based electrochemical sensors for a microfluidic device

C. Karuwan, ORCID logo ab   A. Wisitsoraat,b   P. Chaisuwan,c   D. Nacapricha*a  and  A. Tuantranont*b  

* Corresponding authors

a Flow Innovative Research for Science and Technology Laboratories (FIRST Labs.), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Rama VI Rd, Bangkok 10400, Thailand
E-mail: duangjai.nac@mahidol.ac.th
Fax: +66-2-354-7165
Tel: +66-2-201-5007

b Thai Organic and Printed Electronics Innovation Center, National Electronics and Computer Technology Center (NECTEC), 112 Paholyothin Rd., Klong 1, Klong Luang, Pathumthani, Thailand
E-mail: adisorn.tuantranont@nectec.or.th
Fax: +66-2-564-6756

c School of Chemistry, Institute of Science, Suranaree University of Technology, 111 University Avenue, Muang District, Nakhon Ratchasima 30000, Thailand

Abstract

This work presents a new method for mass fabrication of a new microfluidic device with integrated graphene-based electrochemical electrodes by the screen printing technique for in-channel amperometric detection. Graphene-based working and counter electrodes were fabricated by screen printing graphene paste on a glass substrate, followed by screen printing of a silver/silver chloride (Ag/AgCl) reference electrode. The screen-printed substrate was then bonded to a prefabricated polydimethylsiloxane (PDMS) sheet containing microchannels via oxygen plasma treatment. The developed microfluidic device was then applied for glutathione analysis in pharmaceutical products. The method offers effective and fast glutathione detection with good analytical features including a wide dynamic range (10–500 μM) and a low detection limit (3 μM). In addition, the screen printed graphene electrode (SPGE) exhibits a good stability in a microfluidic flow system and good repeatability for amperometric detection. The method has numerous advantages including low fabrication cost, high sensitivity, high throughput and satisfactory reproducibility. Thus, it holds great promise for advanced analytical applications.

Graphical abstract: Screen-printed graphene-based electrochemical sensors for a microfluidic device

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Article information

DOI
https://doi.org/10.1039/C7AY00379J
Article type
Paper
Submitted
15 Feb 2017
Accepted
15 May 2017
First published
16 May 2017

Anal. Methods, 2017,9, 3689-3695

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Screen-printed graphene-based electrochemical sensors for a microfluidic device

C. Karuwan, A. Wisitsoraat, P. Chaisuwan, D. Nacapricha and A. Tuantranont, Anal. Methods, 2017, 9, 3689 DOI: 10.1039/C7AY00379J

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