Issue 24, 2016

Enantioselective total synthesis and structural reassignment of (+)-alsmaphorazine E via a traceless chirality transfer strategy

Abstract

The first enantioselective total synthesis of (+)-alsmaphorazine E has been achieved through a traceless chirality transfer strategy, which also enabled structural reassignment of the natural product. Key features of this efficient approach entail a catalytic intramolecular oxidative cyclization, a diastereoselective oxidative cyclic aminal formation and a radical cyclization/transannular aza-Michael addition cascade.

Graphical abstract: Enantioselective total synthesis and structural reassignment of (+)-alsmaphorazine E via a traceless chirality transfer strategy

Supplementary files

Article information

Article type
Communication
Submitted
29 Jan 2016
Accepted
25 Feb 2016
First published
25 Feb 2016

Chem. Commun., 2016,52, 4485-4488

Enantioselective total synthesis and structural reassignment of (+)-alsmaphorazine E via a traceless chirality transfer strategy

K. Yu, B. Gao, Z. Liu and H. Ding, Chem. Commun., 2016, 52, 4485 DOI: 10.1039/C6CC00930A

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