Issue 27, 2016
From the journal:

Chemical Communications

Metal ion triggers for reversible switching of DNA polymerase†

Ki Soo Park,a   Chang Yeol Leea  and  Hyun Gyu Park*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering (BK 21+ program), KAIST, Daejeon 305-338, Republic of Korea
E-mail: hgpark@kaist.ac.kr
Fax: +82-42-350-3910
Tel: +82-42-350-3932

Abstract

We herein develop a new strategy that modulates DNA polymerase activity in a reversible and switchable manner by using the novel interactions between DNA bases and metal ions (T–Hg2+–T and C–Ag+–C) inside a DNA aptamer capable of inhibiting DNA polymerase.

Graphical abstract: Metal ion triggers for reversible switching of DNA polymerase

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Article information

DOI
https://doi.org/10.1039/C6CC00454G
Article type
Communication
Submitted
17 Jan 2016
Accepted
17 Feb 2016
First published
17 Feb 2016

Chem. Commun., 2016,52, 4868-4871

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Metal ion triggers for reversible switching of DNA polymerase

K. S. Park, C. Y. Lee and H. G. Park, Chem. Commun., 2016, 52, 4868 DOI: 10.1039/C6CC00454G

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