Issue 118, 2015
From the journal:

RSC Advances

A fluorescence active gold nanorod–quantum dot core–satellite nanostructure for sub-attomolar tumor marker biosensing†

Xiaoling Wu,a   Fengli Gao,a   Liguang Xu,a   Hua Kuang,*a   Libing Wanga  and  Chuanlai Xua  

* Corresponding authors

a State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 214122, Wuxi, JiangSu, People’s Republic of China
E-mail: kuangh@jiangnan.edu.cn
Tel: +86-0510-85329076

Abstract

The accurate monitoring of trace cancer biomarkers is crucial for the early diagnosis of cancer. In the present study, we constructed a gold nanorod–quantum dot core–satellite assembly using a PSA-aptamer and its complementary DNA and developed an ultrasensitive fluorescence-aptasensor for the detection of prostate specific antigen (PSA) by monitoring fluorescence intensity. The limit of detection (LOD) for PSA was 0.029 aM, with an excellent linear range from 0.1 aM to 10 aM. This super-sensitive aptasensor was demonstrated to be robust in the analysis of human serum samples, and shows great potential for early cancer diagnosis and therapy.

Graphical abstract: A fluorescence active gold nanorod–quantum dot core–satellite nanostructure for sub-attomolar tumor marker biosensing

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Article information

DOI
https://doi.org/10.1039/C5RA19628K
Article type
Paper
Submitted
23 Sep 2015
Accepted
05 Nov 2015
First published
09 Nov 2015

RSC Adv., 2015,5, 97898-97902

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A fluorescence active gold nanorod–quantum dot core–satellite nanostructure for sub-attomolar tumor marker biosensing

X. Wu, F. Gao, L. Xu, H. Kuang, L. Wang and C. Xu, RSC Adv., 2015, 5, 97898 DOI: 10.1039/C5RA19628K

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