Self-propelled carbon nanotube based microrockets for rapid capture and isolation of circulating tumor cells

Shashwat S. Banerjee; Archana Jalota-Badhwar; Khushbu R. Zope; Kiran J. Todkar; Russel R. Mascarenhas; Govind P. Chate; Ganesh V. Khutale; Atul Bharde; Marcelo Calderon; Jayant J. Khandare

doi:10.1039/C5NR01797A

Self-propelled carbon nanotube based microrockets for rapid capture and isolation of circulating tumor cells†

Shashwat S. Banerjee,^a Archana Jalota-Badhwar,^b Khushbu R. Zope,^c Kiran J. Todkar,^a Russel R. Mascarenhas,^b Govind P. Chate,^c Ganesh V. Khutale,^a Atul Bharde,^a Marcelo Calderon^d and Jayant J. Khandare*^ac

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* Corresponding authors

^a Actorius Innovations and Research (AIR), 100 NCL Innovation Park, Pune-411008, India
E-mail: jayant.khandare@mippune.edu.in

^b Cancer Biology Group, Piramal Life Sciences Ltd., Mumbai-400063, India

^c Maharashtra Institute of Pharmacy, MIT Campus, Pune-411038, India

^d Institut für Chemie, Freie Universität Berlin, 14195 Berlin, Germany

Abstract

Here, we report a non-invasive strategy for isolating cancer cells by autonomously propelled carbon nanotube (CNT) microrockets. H₂O₂-driven oxygen (O₂) bubble-propelled microrockets were synthesized using CNT and Fe₃O₄ nanoparticles in the inner surface and covalently conjugating transferrin on the outer surface. Results show that self-propellant microrockets can specifically capture cancer cells.

Nanoscale

Self-propelled carbon nanotube based microrockets for rapid capture and isolation of circulating tumor cells†

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Self-propelled carbon nanotube based microrockets for rapid capture and isolation of circulating tumor cells

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